Comparing the effects of magnesium sulfate and lidocaine spray on hemodynamic changes caused by laryngoscopy and tracheal intubation: a randomized clinical trial.

Plain-language guide to PMID 39948445 (2025): double-blind randomized controlled trial of Vitamin D, K2, Magnesium and Zinc in 100 patients.

Key Facts

PMID: 39948445
Journal: BMC anesthesiology
Year: 2025
Study type: Randomized Controlled Trial
Authors: Khalaji M et al. (5 authors)
DOI: 10.1186/s12871-025-02962-x

What This Study Did, in Plain Language

What Was Tested

Researchers studied Vitamin D, K2, Magnesium and Zinc in this randomized controlled trial publication.

This study aims at comparing the impact of Magnesium Sulfate and Lidocaine sprays on hemodynamic changes after laryngoscopy and tracheal intubation.

Who Took Part

According to the abstract, 100 patients were involved.

The age groups tagged for this paper are teenagers, young adults and adults, both men and women.

This double-blind clinical trial (code IRCT20230719058846N1) was conducted on the patients undergoing elective surgery in the city of Karaj.

A total of 100 patients, aged 18 to 40 years and classified as ASA I or II, who were candidates for elective surgery, were randomly assigned to two equal groups.

How the Study Was Run

In design terms this was a randomized and double-blind study.

Random assignment meant chance, not the researchers, decided who got Vitamin D, K2, Magnesium and Zinc and who got the comparison, which limits bias.

As a double-blind Vitamin D, K2, Magnesium and Zinc study, the assignments were hidden from both participants and investigators until the end.

Induction of anesthesia was the same in both groups.

Patients' hemodynamic statuses were measured and compared once before the intubation and also 1, 3, 5, 7 and 10 min after it.

What Was Measured

The subject headings attached to it are Lidocaine, Magnesium Sulfate, Intubation, Intratracheal, Laryngoscopy, Hemodynamics, Anesthetics, Local and Blood Pressure.

Author keywords: Endotracheal intubation, Hemodynamic response, Lidocaine spray and Magnesium sulfate spray.

What This Means in Plain Language

The paper is a randomized and double-blind study of Vitamin D, K2, Magnesium and Zinc in 100 patients.

Results are reported in around 6 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 2025 (BMC anesthesiology), a journal based in England.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.

Our Notes on the Compound

Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.

Vitamin D, K2, Magnesium and Zinc in the library

Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.