The auxiliary effect of vitamin D in the treatment of chronic rhinosinusitis with nasal polyposis, a clinical trial.

What Was Tested

Researchers studied Vitamin D, K2, Magnesium and Zinc in this randomized controlled trial publication.

Chronic Rhinosinusitis with Nasal Polyposis (CRSwNP) is a prevalent chronic inflammatory disorder of the nasal cavity and paranasal sinus with benign polypoid masses.

Who Took Part

According to the abstract, 59 patients were involved.

The age groups tagged for this paper are adults and middle-aged adults, both men and women.

This randomized, double-blind clinical trial was conducted on 59 patients with CRSwNP.

All patients with Vit D deficiency (25OH Vit D level < 20 ng/mL) or insufficiency (<30 ng/mL) underwent endoscopic sinus surgery (ESS).

How the Study Was Run

In design terms this was a randomized and double-blind study.

The patients were allocated by chance, so the Vitamin D, K2, Magnesium and Zinc group and the comparison group should start out alike.

Neither the patients nor the staff measuring them knew who was on Vitamin D, K2, Magnesium and Zinc, so expectations could not easily colour the readings.

The rate of changes in the patients' symptoms were recorded before and 8 weeks after the surgery.

What Was Measured

PubMed files the paper under topics including Nasal Polyps, Sinusitis, Rhinitis, Vitamin D, Chronic Disease, Endoscopy and Vitamin D Deficiency.

Author keywords: anti-proliferative agents, chronic rhinosinusitis and sinonasal polyposis.

What This Means in Plain Language

The paper is a randomized and double-blind study of Vitamin D, K2, Magnesium and Zinc in 59 patients.

Its findings take up roughly 4 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2025 (Acta oto-laryngologica), a journal based in England.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.