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Short Report: Influence of Dark Chocolate Intake on Magnesium Status in Hemodialysis Patients.
Plain-language guide to PMID 40020766 (2025): pilot clinical trial of Vitamin D, K2, Magnesium and Zinc in 59 patients.
Key Facts
- PMID
- 40020766
- Journal
- Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation
- Year
- 2025
- Study type
- Clinical Trial
- Authors
- Kemp JA et al. (7 authors)
- DOI
- 10.1053/j.jrn.2025.02.002
- Registered trial
- NCT04600258
What This Study Did, in Plain Language
What Was Tested
This clinical trial looks at Vitamin D, K2, Magnesium and Zinc.
Dark chocolate is an excellent source of Mg2+.
Who Took Part
The study group was 59 patients.
PubMed indexes the participants as adults and middle-aged adults, both men and women.
The study included 59 patients undergoing HD.
Patients were allocated into 2 groups: dark chocolate and the control group.
How the Study Was Run
The researchers set it up as a pilot study.
It is described as a pilot, a small early test of whether a larger Vitamin D, K2, Magnesium and Zinc study would be practical.
These are secondary analyses from a previous controlled pilot study.
The control group did not receive any intervention.
Mg2+ was evaluated by a colorimetric test using a commercial kit (Bioclin®).
NCT04600258 on March 1, 2020, retrospectively registered.
What Was Measured
PubMed files the paper under topics including Chocolate, Magnesium, Magnesium Deficiency, Pilot Projects, Renal Dialysis and Renal Insufficiency, Chronic.
The authors tagged it with the keywords bioactive compounds, chronic kidney disease, dark chocolate and hemodialysis.
What This Means in Plain Language
The paper is a pilot study of Vitamin D, K2, Magnesium and Zinc in 59 patients.
Results are reported in around 6 sentences of the abstract; we leave them to the paper itself rather than summarise them.
The publication is from 2025 (Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation), a journal based in United States.
More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.
Our Notes on the Compound
Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.