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Cryoanalgesia for Pain Management After Pectus Excavatum Repair (COPPER) in Adolescents: A Randomized Controlled Trial.
Plain-language guide to PMID 40035332 (2025): parallel-group randomized controlled trial of Copper (Supplement).
Key Facts
- PMID
- 40035332
- Journal
- Paediatric anaesthesia
- Year
- 2025
- Study type
- Randomized Controlled Trial
- Authors
- Bastianello M et al. (9 authors)
- DOI
- 10.1111/pan.15090
- Registered trial
- NCT05201820
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of Copper (Supplement), published as a randomized controlled trial.
Patients undergoing Pectus Excavatum repair with the minimally invasive approach frequently report severe postoperative pain.
Who Took Part
By PubMed's age tags, the people studied were children and teenagers, both men and women.
A randomized, active controlled, parallel groups trial (category IIb medical device) was designed for patients undergoing pectus excavatum repair.
Participants were screened from the elective surgical lists at Istituto Gaslini, Genova, Italy, and they all were part of the academic practice setting.
How the Study Was Run
The design is described as randomized and parallel-group.
Because people in this Copper (Supplement) study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.
The Copper (Supplement) group and the comparison group ran side by side rather than switching.
Once enrolled, patients were randomly assigned to one of the two study arms: cryoanalgesia vs. standard of care (epidural-based analgesia).
The primary outcome was the Pediatric Quality of Life (PedsQL) and the subcomponents (psychosocial and physical health) 14 days after surgery.
What Was Measured
The subject headings attached to it are Funnel Chest, Postoperative Pain, Pain Management, Quality of Life and Cryotherapy.
The authors tagged it with the keywords anesthesia, complications, cryanalgesia, pectus excavatum and pediatric.
What This Means in Plain Language
The paper is a randomized and parallel-group study of Copper (Supplement).
The abstract goes on to report its results in about 7 sentences; this page does not restate them, so read the paper for the findings and their limits.
The publication is from 2025 (Paediatric anaesthesia), a journal based in France.
More context: the Copper (Supplement) compound page, all human trials.
Our Notes on the Compound
Copper (Supplement): The active site of cytochrome c oxidase is described as containing copper ions that are essential for electron transfer.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.