Effect of perioperative magnesium sulfate on neurological outcome in neurosurgical patients: a randomized double-blind controlled trial.

What Was Tested

The paper reports a study of Vitamin D, K2, Magnesium and Zinc, published as a randomized controlled trial.

Supplemental magnesium sulfate has a potential neuroprotective role in acute brain injury.

This study evaluated the effect of perioperative intravenous administration of magnesium sulfate on brain damage caused by neurosurgery.

Who Took Part

PubMed indexes the participants as adults, middle-aged adults and older adults, both men and women.

Fifty adult patients undergoing supratentorial neurosurgery (25 were assigned to magnesium sulfate group and 26 to the control group).

How the Study Was Run

In design terms this was a randomized and double-blind study.

The participants were allocated by chance, so the Vitamin D, K2, Magnesium and Zinc group and the comparison group should start out alike.

As a double-blind Vitamin D, K2, Magnesium and Zinc study, the assignments were hidden from both participants and investigators until the end.

Prospective randomized double-blind controlled study.

The control group received the same volume of saline.

Serum S100B-protein levels 2 h after surgery was the primary outcome.

Secondary outcomes were neuron-specific enolase, magnetic resonance imaging (MRI) parameters, neuropsychological testing, Glasgow Outcome Scale, and mortality, during hospital stay and at six and 12 months after surgery.

What Was Measured

This study evaluated the effect of perioperative intravenous administration of magnesium sulfate on brain damage caused by neurosurgery.

PubMed files the paper under topics including Magnesium Sulfate, Neurosurgical Procedures, Perioperative Care, Neuroprotective Agents, Postoperative Complications and Magnetic Resonance Imaging.

What This Means in Plain Language

The paper is a randomized and double-blind study of Vitamin D, K2, Magnesium and Zinc.

Its findings take up roughly 5 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2025 (Minerva anestesiologica), a journal based in Italy.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.