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Effects of One-Year Menaquinone-7 Supplementation on Vascular Stiffness and Blood Pressure in Post-Menopausal Women
Plain-language guide to PMID 40077685 (2025): double-blind randomized controlled trial study of Vitamin D, K2, Magnesium and Zinc in 165 women, low blood pressure and orthostatic hypotension.
Key Facts
- PMID
- 40077685
- Journal
- Nutrients
- Year
- 2025
- Study type
- Randomized Controlled Trial
- Authors
- de Vries F et al. (7 authors)
- DOI
- 10.3390/nu17050815
What This Study Did, in Plain Language
What Was Tested
This randomized controlled trial paper looks at Vitamin D, K2, Magnesium and Zinc in the context of low blood pressure and orthostatic hypotension.
The aim of the post hoc analysis of this one-year study is to investigate the effects of MK-7 supplementation on the vascular parameters in pre-, peri-, and post-menopausal women.
Why It Was Studied
Menaquinone-7 (MK-7) is a fat-soluble vitamin involved in coagulation and maintaining vascular health.
Pre-, peri-, and post-menopausal women were subdivided according to arterial stiffness, with a high b-stiffness index defined as being greater than the overall median of 9.83.
Who Took Part
The study group was 165 women.
PubMed indexes the participants as middle-aged adults and older adults, women only.
Established vascular parameters were measured before and after one year of vitamin K2 supplementation.
How the Study Was Run
The design is described as randomized, double-blind and placebo-controlled.
The women were allocated by chance, so the Vitamin D, K2, Magnesium and Zinc group and the comparison group should start out alike.
Neither the women nor the staff measuring them knew who was on Vitamin D, K2, Magnesium and Zinc, so expectations could not easily colour the readings.
Some women received a placebo instead of Vitamin D, K2, Magnesium and Zinc, giving a reference point.
The timeline in the abstract includes one year.
What Was Measured
The subject headings attached to it are Vitamin K 2, Postmenopause, Vascular Stiffness, Dietary Supplements, Blood Pressure, Calcium-Binding Proteins and Matrix Gla Protein.
Author keywords: post-menopause, pre/peri-menopause and vitamin k homeostasis.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc in 165 women in people with low blood pressure and orthostatic hypotension over one year.
The publication is from 2025 (Nutrients), a journal based in Switzerland.
More context: the Vitamin D, K2, Magnesium and Zinc compound page, Low blood pressure and orthostatic hypotension research.
Our Notes on the Compound
Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.
Related Pages
- Low blood pressure and orthostatic hypotension research
- Vitamin D, K2, Magnesium and Zinc in the library
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.