Threshold-dependent risk of postoperative hypocalcemia in vitamin D-deficient patients undergoing total thyroidectomy: A meta-analysis.

What It Covers

This meta-analysis looks at Vitamin D, K2, Magnesium and Zinc.

The purpose of this study was to investigate the threshold effect in the relationship between vitamin D deficiency and the incidence of postoperative hypocalcemia.

Why It Was Studied

Vitamin D deficiency is common and asymptomatic in many populations, and research reveals an association between vitamin D levels and postoperative hypocalcemia after total thyroidectomy.

However, the definition of vitamin D deficiency has varied, and the threshold used might have a major impact on clinical results.

Who the Included Studies Covered

PubMed tags the participants as both men and women.

A meta-analysis was done following Preferred Reporting Items for Systematic reviews and Meta-Analyses recommendations.

Studies that examined preoperative vitamin D levels and assessed postoperative hypocalcemia in total thyroidectomy patients were included.

How the Review Was Done

The investigation explored 3 vitamin D insufficiency thresholds: 15, 20, and 30 ng/mL.

The methodologic quality was assessed using the Quality In Prognosis Studies technique.

What Was Measured

Vitamin D deficiency is common and asymptomatic in many populations, and research reveals an association between vitamin D levels and postoperative hypocalcemia after total thyroidectomy.

PubMed files the paper under topics including Hypocalcemia, Thyroidectomy, Vitamin D Deficiency, Postoperative Complications, Incidence, Risk Factors and Vitamin D.

What This Means in Plain Language

This is a meta-analysis of Vitamin D, K2, Magnesium and Zinc.

The abstract goes on to report its results in about 5 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2025 (Surgery), a journal based in United States.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.