Serum 25-Hydroxyvitamin D and Intact Parathyroid Hormone as Functional Biomarkers of Bone Mass in Early Childhood

What Was Tested

Researchers studied Parathyroid Hormone (PTH 1-84) in this observational study publication.

To determine whether the threshold of 25(OH)D at PTH suppression in young children is corroborated by associations of 25(OH)D (or PTH) with bone mineral content (BMC) and areal bone mineral density (aBMD).

Why It Was Studied

The 25-hydroxyvitamin D (25(OH)D) concentration at which parathyroid hormone (PTH) concentration plateaus has been considered to benchmark vitamin D deficiency.

However, in young children, there is limited evidence for a suppression point in the 25(OH)D-PTH relationship or its relevance to bone mass accrual.

Who Took Part

The age groups tagged for this paper are young children, both men and women.

In a cross-sectional secondary analysis of data from the BONe and mUScle health in Kids (BONUSKids) study of 4-y-old children in Bangladesh, serum 25(OH)D and intact PTH (iPTH) were analyzed by liquid chromatography-tandem mass spectrometry and a chemiluminescent immunoassay, respectively.

Model fit was compared using Akaike's Information Criteria.

How the Study Was Run

BMC and aBMD were measured by dual-energy X-ray absorptiometry.

Associations between 25(OH)D, iPTH, and bone outcomes (BMC, BMC z-score, aBMD, and aBMD z-score) were modeled using multivariable-adjusted linear regression and spline models.

What Was Measured

PubMed files the paper under topics including Absorptiometry, Photon, Bangladesh, Biomarkers, Bone and Bones, Bone Density, Cross-Sectional Studies and Parathyroid Hormone.

The authors tagged it with the keywords 25-hydroxyvitamin D, bone mineral content, bone mineral density, child, low- and middle-income countries and vitamin D.

What This Means in Plain Language

This is an observational study of Parathyroid Hormone (PTH 1-84).

Its findings take up roughly 7 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2025 (The Journal of nutrition), a journal based in United States.

More context: the Parathyroid Hormone (PTH 1-84) compound page, all human trials.