A Mitochondrial Supplement Improves Function and Mitochondrial Activity in Autism: A Double-Blind Placebo-Controlled Cross-Over Trial.

What Was Tested

This randomized controlled trial looks at Copper (Supplement).

Mitochondrial respiration of peripheral blood mononuclear cell respiration, as measured by the Seahorse XFe96 (Agilent, Santa Clara, CA, USA) with the mitochondrial oxidative stress test, became more resilient to oxidative stress after the treatment, particularly in children with poor neurodevelopment.

Who Took Part

By PubMed's age tags, the people studied were children, both men and women.

How the Study Was Run

In design terms this was a randomized, double-blind, placebo-controlled and crossover study.

The participants were allocated by chance, so the Copper (Supplement) group and the comparison group should start out alike.

Neither the participants nor the staff measuring them knew who was on Copper (Supplement), so expectations could not easily colour the readings.

A placebo (an inactive look-alike) gave the Copper (Supplement) group a baseline to be compared against.

Each person switched between Copper (Supplement) and the comparison at some point, usually with a gap in between.

Which product was received first was randomized.

What Was Measured

Mitochondrial respiration of peripheral blood mononuclear cell respiration, as measured by the Seahorse XFe96 (Agilent, Santa Clara, CA, USA) with the mitochondrial oxidative stress test, became more resilient to oxidative stress after the treatment, particularly in children with poor neurodevelopment.

Topics PubMed links to this paper include Mitochondria, Dietary Supplements, Autism Spectrum Disorder, Autistic Disorder and Oxidative Stress.

Author keywords: clinical trial, nutritional supplement and respirometry.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Copper (Supplement).

The publication is from 2025 (International journal of molecular sciences), a journal based in Switzerland.

More context: the Copper (Supplement) compound page, all human trials.