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A comparative analysis of the efficacy of intrauterine misoprostol in conjunction with oxytocin versus oxytocin monotherapy for the prophylaxis of primary postpartum haemorrhage

Plain-language guide to PMID 40143472 (2025): randomized controlled trial study of Oxytocin in 2021, women.

Key Facts

PMID
40143472
Journal
JPMA. The Journal of the Pakistan Medical Association
Year
2025
Study type
Randomized Controlled Trial
Authors
Rizwan A et al. (6 authors)
DOI
10.47391/JPMA.11080

What This Study Did, in Plain Language

What Was Tested

The paper reports a study of Oxytocin, published as a randomized controlled trial.

Who Took Part

The abstract describes 2021, women taking part.

The age groups tagged for this paper are young adults and adults, women only.

The quasi-randomised controlled trial took place at the Akbar Niazi Teaching Hospital, Islamabad, Pakistan, from February to August 2021, and comprised women who underwent lower segment caesarean section and at fullterm pregnancy who had risk factors for experiencing postpartum haemorrhage.

The subjects were randomised into experimental group A and control group B.

How the Study Was Run

The design is described as randomized.

The women were allocated by chance, so the Oxytocin group and the comparison group should start out alike.

Group A subjects received both misoprostol and oxytocin, while those in group B received oxytocin only.

Data was analysed using SPSS 26.

What Was Measured

PubMed files the paper under topics including Postpartum Hemorrhage, Misoprostol, Oxytocin, Oxytocics, Cesarean Section and Pakistan.

The authors tagged it with the keywords Postpartum haemorrhage, Misoprostol, Oxytocin, Postoperative blood loss..

What This Means in Plain Language

The paper is a randomized study of Oxytocin in 2021, women.

With several hundred people or more, it is a fairly large study for this kind of research.

The abstract goes on to report its results in about 5 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2025 (JPMA. The Journal of the Pakistan Medical Association), a journal based in Pakistan.

More context: the Oxytocin compound page, all human trials.

Our Notes on the Compound

Oxytocin: A peptide hormone with established obstetric medical uses and a less settled role in research on behavior, sexual function and appetite.

Related Pages

Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.