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Effects of Coenzyme Q10, Tryptophan, and Magnesium Supplementation on Fatigue in Patients with Fibromyalgia - A Randomized Trial.
Plain-language guide to PMID 40151031 (2025): double-blind randomized controlled trial of Vitamin D, K2, Magnesium and Zinc in 110 patients.
Key Facts
- PMID
- 40151031
- Journal
- Journal of dietary supplements
- Year
- 2025
- Study type
- Randomized Controlled Trial
- Authors
- Rosselló Aubach L et al. (3 authors)
- DOI
- 10.1080/19390211.2025.2483269
What This Study Did, in Plain Language
What Was Tested
Researchers studied Vitamin D, K2, Magnesium and Zinc in this randomized controlled trial publication.
The objective of the study was to assess the effects of CoQ10, tryptophan, and magnesium supplementation in patients with FM.
Why It Was Studied
The study comprised two periods of three months each, and a one-month washout period between them.
The primary endpoint was the change in the item fatigue of the combined index of fibromyalgia impact in patients (ICAF).
Who Took Part
According to the abstract, 110 patients were involved.
PubMed indexes the participants as adults and middle-aged adults, both men and women.
Participants were randomized to receive the dietary supplement or placebo.
How the Study Was Run
The researchers set it up as a randomized, double-blind, placebo-controlled and crossover study.
The patients were allocated by chance, so the Vitamin D, K2, Magnesium and Zinc group and the comparison group should start out alike.
Neither the patients nor the staff measuring them knew who was on Vitamin D, K2, Magnesium and Zinc, so expectations could not easily colour the readings.
Some patients received a placebo instead of Vitamin D, K2, Magnesium and Zinc, giving a reference point.
Each person switched between Vitamin D, K2, Magnesium and Zinc and the comparison at some point, usually with a gap in between.
What Was Measured
The primary endpoint was the change in the item fatigue of the combined index of fibromyalgia impact in patients (ICAF).
Secondary outcomes included changes in the remaining ICAF factors and items and in the total score.
The subject headings attached to it are Ubiquinone, Dietary Supplements, Fibromyalgia, Fatigue, Tryptophan, Magnesium and Sleep Quality.
Author keywords: Coenzyme Q10.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc in 110 patients.
The publication is from 2025 (Journal of dietary supplements), a journal based in England.
More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.
Our Notes on the Compound
Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.