Influence of magnesium sulfate on the pharmacodynamic characteristics of rocuronium. A randomized clinical trial.

What Was Tested

The paper reports a study of Vitamin D, K2, Magnesium and Zinc, published as a randomized controlled trial.

As a multimodal anesthesia adjuvant, magnesium sulfate (MgSO4) plays an important role in the anesthetic arsenal, due to its properties and substantial synergistic effects with other drugs such as opioids, hypnotics and neuromuscular blocking drugs (NMBD).

Rocuronium is a non-depolarizing NMBD used widely in general anesthesia, and its association with MgSO4 is still a concern.

Who Took Part

According to the abstract, 70 patients were involved.

The age groups tagged for this paper are adults and middle-aged adults, women only.

It was a double-blinded, randomized controlled trial in adult female patients scheduled for open hysterectomies with total intravenous anesthesia.

In total, 70 patients were enrolled, 35 per group.

How the Study Was Run

The researchers set it up as a randomized and double-blind study.

The patients were allocated by chance, so the Vitamin D, K2, Magnesium and Zinc group and the comparison group should start out alike.

As a double-blind Vitamin D, K2, Magnesium and Zinc study, the assignments were hidden from both participants and investigators until the end.

What Was Measured

The subject headings attached to it are Magnesium Sulfate, Rocuronium, Neuromuscular Nondepolarizing Agents and Hysterectomy.

Author keywords: anesthesia.

What This Means in Plain Language

The paper is a randomized and double-blind study of Vitamin D, K2, Magnesium and Zinc in 70 patients.

Results are reported in around 4 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 2025 (Anaesthesiology intensive therapy), a journal based in Poland.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.