Administration of Calcium and Magnesium in Acute Intracerebral Hemorrhage Patients: Assessing Safety and Feasibility.

What Was Tested

The paper reports a study of Vitamin D, K2, Magnesium and Zinc, published as a randomized controlled trial.

Serum calcium and magnesium levels are a key factor of the coagulation cascade and may potentially contribute to the pathophysiology of intracerebral hemorrhage (ICH) expansion.

Clinical Research Information Service Identifier: KCT0004427.

Who Took Part

By PubMed's age tags, the people studied were teenagers, young adults, adults, middle-aged adults, older adults and people over 80, both men and women.

A single-blind, prospective, multicenter randomized study was conducted from 2019 to 2022 years, enrolling acute ICH patients aged 18-80 years, with radiological diagnosis and without surgical intervention.

Participants were randomly assigned in a 1:1 ratio to either the study group or the control group.

How the Study Was Run

The design is described as randomized, single-blind and multicenter.

The participants were allocated by chance, so the Vitamin D, K2, Magnesium and Zinc group and the comparison group should start out alike.

Only one side, usually the participants, was kept unaware of whether Vitamin D, K2, Magnesium and Zinc was given.

Running at several centres spread the Vitamin D, K2, Magnesium and Zinc study over different clinics and patient groups.

The primary outcome was the expansion of ICH volume within the first 3 days between the study group and the control groups.

What Was Measured

Serum calcium and magnesium levels are a key factor of the coagulation cascade and may potentially contribute to the pathophysiology of intracerebral hemorrhage (ICH) expansion.

The subject headings attached to it are Magnesium, Calcium, Cerebral Hemorrhage, Glasgow Coma Scale and Acute Disease.

Author keywords: Cerebrovascular Hematoma, Intracerebral Hemorrhage and Stroke.

What This Means in Plain Language

The paper is a randomized, single-blind and multicenter study of Vitamin D, K2, Magnesium and Zinc.

The abstract goes on to report its results in about 6 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2025 (Journal of Korean medical science), a journal based in Korea (South).

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.