Evaluation of in vivo supplementation of D-aspartic acid and ubiquinol and zinc on different semen parameters in idiopathic male infertility: a randomized double blind placebo controlled study.

What Was Tested

Researchers studied Vitamin D, K2, Magnesium and Zinc in this randomized controlled trial publication.

The current study is one of the first to evaluate the in vivo supplementation of D-aspartic acid in idiopathic male infertility.

Thus, the researchers aimed in the current study to evaluate the in vivo effect of D-aspartic acid, zinc and co-enzyme Q 10 supplementation on different semen parameters and serum testosterone level in idiopathic male infertility.

Why It Was Studied

Idiopathic male subfertility is the commonest cause in most cases.

D-aspartic acid (D-Asp) is an endogenous amino acid occurring in several tissues and cells of both invertebrates and vertebrates.

Who Took Part

The abstract describes 75 patients taking part.

The age groups tagged for this paper are adults, men only.

A total of 75 infertile patients were recruited from the outpatient andrology clinic from March 2023 to June 2024.

How the Study Was Run

In design terms this was a randomized, double-blind and placebo-controlled study.

Random assignment meant chance, not the researchers, decided who got Vitamin D, K2, Magnesium and Zinc and who got the comparison, which limits bias.

As a double-blind Vitamin D, K2, Magnesium and Zinc study, the assignments were hidden from both participants and investigators until the end.

Some patients received a placebo instead of Vitamin D, K2, Magnesium and Zinc, giving a reference point.

The current study was registered at the UMIN clinical registry trials prior to initiating the study (UMIN000050023).

What Was Measured

The subject headings attached to it are Zinc, D-Aspartic Acid, Infertility, Male, Dietary Supplements, Semen Analysis, Ubiquinone and Testosterone.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc in 75 patients.

The abstract goes on to report its results in about 3 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2025 (Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica), a journal based in Italy.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.