Craniofacial Changes Among Children and Adolescents Submitted to Growth Hormone Therapy: A Systematic Review.

What It Covers

Researchers studied Exogenous HGH, sermorelin & older GHRPs (why they're passed over) in this systematic review publication.

The aim of this systematic review was to investigate the association between craniofacial changes and growth hormone (GH) therapy among children and adolescents with GH deficiency or idiopathic short stature (ISS).

Why It Was Studied

An electronic search was conducted in seven databases, without year or language restrictions.

The study selection was carried out in two stages by two calibrated examiners.

Who the Included Studies Covered

By PubMed's age tags, the people studied were children and teenagers.

Studies exploring craniofacial changes among children and adolescents with GH deficiency or ISS undergoing GH therapy were included.

How the Review Was Done

The PRISMA guideline was followed to carry out all stages of this review.

After data extraction, the risk of bias was assessed using the Joanna Briggs Institute (JBI) Critical Appraisal tool and the RoB 2.0 Checklist.

The certainty of the evidence was assessed using the GRADE tool.

What Was Measured

These studies evaluated the impact of GHs on cephalometric measurements and dental age.

The subject headings attached to it are Human Growth Hormone, Cephalometry, Growth Disorders, Skull and Growth Hormone.

Author keywords: face, growth and development and orthodontics.

What This Means in Plain Language

This is a systematic review of Exogenous HGH, sermorelin & older GHRPs (why they're passed over).

The publication is from 2025 (Orthodontics & craniofacial research), a journal based in England.

More context: the Exogenous HGH, sermorelin & older GHRPs (why they're passed over) compound page, all human trials.