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Serum Copper Levels in Chronic Kidney Disease and Hemodialysis Patients: Insights from a Systematic Review and Meta-Analysis.
Plain-language guide to PMID 40304970 (2025): meta-analysis of Copper (Supplement), chronic and systemic inflammation.
Key Facts
- PMID
- 40304970
- Journal
- Biological trace element research
- Year
- 2025
- Study type
- Meta-Analysis
- Authors
- Aldalati AY et al. (7 authors)
- DOI
- 10.1007/s12011-025-04647-5
What This Paper Covers, in Plain Language
What It Covers
Researchers studied Copper (Supplement) in the context of chronic and systemic inflammation in this meta-analysis publication.
Copper is an essential trace element involved in numerous enzymatic functions and physiological processes.
Chronic kidney disease (CKD) and hemodialysis (HD) may influence copper homeostasis, yet conflicting findings exist regarding copper levels in these patients and copper levels aren't routinely checked.
Who the Included Studies Covered
Observational studies reporting serum copper levels in CKD and HD patients were included.
How the Review Was Done
A systematic search of PubMed, Scopus, Cochrane Library, EMBASE, and Web of Science was conducted up to February 2025.
Data analysis were conducted using RevMan software.
The data were pooled as standardized mean difference (SMD) and using a random-effects model.
What Was Measured
Chronic kidney disease (CKD) and hemodialysis (HD) may influence copper homeostasis, yet conflicting findings exist regarding copper levels in these patients and copper levels aren't routinely checked.
This systematic review and meta-analysis evaluates serum copper concentrations in CKD and HD patients compared to healthy controls (HC), and assesses changes pre- and post-HD.
The subject headings attached to it are Copper, Renal Dialysis and Renal Insufficiency, Chronic.
Author keywords: Chronic kidney disease, Hemodialysis, Meta-analysis, Serum copper and Systematic review.
What This Means in Plain Language
This is a meta-analysis of Copper (Supplement) in people with chronic and systemic inflammation.
The abstract goes on to report its results in about 6 sentences; this page does not restate them, so read the paper for the findings and their limits.
The publication is from 2025 (Biological trace element research), a journal based in United States.
More context: the Copper (Supplement) compound page, Chronic and systemic inflammation research.
Our Notes on the Compound
Copper (Supplement): The active site of cytochrome c oxidase is described as containing copper ions that are essential for electron transfer.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.