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Vitamin B12 status and metabolic health in women of reproductive age: Population-based biomarker survey.
Plain-language guide to PMID 40349845 (2025): observational study of Cyanocobalamin (Vitamin B12) in 980 women.
Key Facts
- PMID
- 40349845
- Journal
- Clinical nutrition ESPEN
- Year
- 2025
- Study type
- Observational Study
- Authors
- Guetterman HM et al. (14 authors)
- DOI
- 10.1016/j.clnesp.2025.05.011
- Registered trial
- NCT04048330
What This Study Did, in Plain Language
What Was Tested
This observational study looks at Cyanocobalamin (Vitamin B12).
Population-level data among women of reproductive age could inform screening and interventions.
The objective of this analysis was to examine the prevalence of adverse metabolic characteristics (elevated adiposity and central adiposity, hypertension, elevated glycated hemoglobin [HbA1c]) and associations of vitamin B12 status with metabolic characteristics in women as part of a population-based biomarker survey in Southern India.
Linear and binomial regressions were used to examine associations of vitamin B12 status with metabolic characteristics.
Who Took Part
According to the abstract, 980 women were involved.
The age groups tagged for this paper are teenagers, young adults and adults, women only.
Participants (n = 980 women 15-40 y; not pregnant or lactating) were assessed for total vitamin B12, holotranscobalamin, methylmalonic acid, homocysteine, and HbA1c.
Categorical anthropometry assessments and bioelectrical impedance analysis (e.g., whole body (WF%) and trunk (TF%) fat) were assessed among adults (≥18 y).
What Was Measured
PubMed files the paper under topics including Adiposity, Biomarkers, Body Mass Index, Cross-Sectional Studies, Glycated Hemoglobin, Homocysteine and Hypertension.
The authors tagged it with the keywords Body composition, Metabolic health, Overweight, Periconceptional and Vitamin B(12).
What This Means in Plain Language
This is an observational study of Cyanocobalamin (Vitamin B12) in 980 women.
With several hundred people or more, it is a fairly large study for this kind of research.
The abstract goes on to report its results in about 8 sentences; this page does not restate them, so read the paper for the findings and their limits.
The publication is from 2025 (Clinical nutrition ESPEN), a journal based in England.
More context: the Cyanocobalamin (Vitamin B12) compound page, all human trials.
Our Notes on the Compound
Cyanocobalamin (Vitamin B12): A synthetic form of vitamin B12 (cobalamin), an essential nutrient for DNA synthesis, red blood cell formation and neurological function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.