Dexmedetomidine Versus Magnesium Sulfate in Ultrasound-Guided Bilateral Bi-Level Erector Spinae Plane Block in Corrective Scoliosis Surgery: A Randomized Controlled Clinical Trial.

What Was Tested

This randomized controlled trial looks at Vitamin D, K2, Magnesium and Zinc.

There is a scarcity of research regarding the effects of local anesthetic adjuvant drugs in erector spinae plane block (ESPB), especially in scoliosis surgery.

This study aimed to compare dexmedetomidine (DEX) or magnesium sulfate (MgSO 4 ) as adjuvants for bupivacaine in bilateral bi-level ultrasound-guided ESPB (USG-ESPB) in patients undergoing corrective scoliosis surgery.

Who Took Part

According to the abstract, 60 patients were involved.

The age groups tagged for this paper are teenagers, young adults and adults, both men and women.

In this prospective, randomized study, 60 patients aged 14 to 25 years were randomly assigned to 1 of 3 groups (in a 1:1:1 ratio) after induction of general anesthesia.

How the Study Was Run

In design terms this was a randomized study.

Because people in this Vitamin D, K2, Magnesium and Zinc study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

The control group [n=20] received conventional perioperative analgesia.

The primary outcome was time for the first rescue analgesia.

Secondary outcomes included total morphine consumption and pain scores in the first 48 postoperative hours.

What Was Measured

Topics PubMed links to this paper include Dexmedetomidine, Scoliosis, Magnesium Sulfate, Nerve Block, Bupivacaine, Ultrasonography, Interventional and Postoperative Pain.

The authors tagged it with the keywords analgesia, anesthetics, local and pain management.

What This Means in Plain Language

The paper is a randomized study of Vitamin D, K2, Magnesium and Zinc in 60 patients.

The abstract goes on to report its results in about 5 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2025 (The Clinical journal of pain), a journal based in United States.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.