Efficacy of Magnesium Sulphate as an Adjunct to Lignocaine in Inferior Alveolar Nerve Block for Extraction of Mandibular Third Molar-A Split-Mouth Double-Blinded Randomized Controlled Trial.

What Was Tested

This randomized controlled trial looks at Vitamin D, K2, Magnesium and Zinc.

Magnesium sulphate (MgSO4) has reportedly been used to supplement regional blocks and spinal anaesthesia in various surgical procedures.

Methodology: the researchers carried out a double-blinded, randomized, split-mouth study in 26 patients having bilateral impacted MTM.

Who Took Part

The abstract describes 26 patients taking part.

The age groups tagged for this paper are young adults and adults, both men and women.

Patients presenting with impacted MTM bilaterally with a Pederson's score of ≤ 6 were included.

How the Study Was Run

In design terms this was a randomized and double-blind study.

The patients were allocated by chance, so the Vitamin D, K2, Magnesium and Zinc group and the comparison group should start out alike.

As a double-blind Vitamin D, K2, Magnesium and Zinc study, the assignments were hidden from both participants and investigators until the end.

What Was Measured

The primary outcomes evaluated were the onset time, duration of anaesthesia, need for additional injections, and burning sensation during injection.

The subject headings attached to it are Magnesium Sulfate, Lidocaine, Molar, Third, Nerve Block, Tooth Extraction, Mandibular Nerve and Postoperative Pain.

Author keywords: analgesia, disimpaction, lignocaine, magnesium sulphate and third molar surgery.

What This Means in Plain Language

The paper is a randomized and double-blind study of Vitamin D, K2, Magnesium and Zinc in 26 patients.

With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.

The publication is from 2025 (TheScientificWorldJournal), a journal based in United States.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.