Assessment of the effect of routine-dose vitamin D3 supplementation in Chinese women of childbearing age with vitamin D insufficiency

What Was Tested

Researchers studied Parathyroid Hormone (PTH 1-84) in this randomized controlled trial publication.

It was reported that vitamin D deficiency is common in Chinese women of childbearing age.

Who Took Part

By PubMed's age tags, the people studied were teenagers, young adults, adults and middle-aged adults, women only.

Forty-five women of childbearing age (18-50 years) with vitamin D insufficiency [serum total 25(OH)D < 20 ng/mL] were recruited.

How the Study Was Run

The researchers set it up as a randomized and parallel-group study.

The participants were allocated by chance, so the Parathyroid Hormone (PTH 1-84) group and the comparison group should start out alike.

The Parathyroid Hormone (PTH 1-84) group and the comparison group ran side by side rather than switching.

Single-group repeated measures design was performed.

Trends in serum total 25(OH)D and parathyroid hormone (PTH) were observed at baseline, 2, 3, 4, 5, 6, 10, 12, 14, 16, and 26 weeks, while free and bioavailable 25(OH)D and bone turnover markers (BTMs) were dynamically tracked.

The appropriate level of total 25(OH)D was defined as the thresholds at which serum PTH can be maximally suppressed or plateaued and was explored by polynomial comparison and Gaussian process regression.

What Was Measured

Topics PubMed links to this paper include Biomarkers, Bone Density, China, Cholecalciferol, Dietary Supplements, Nutritional Status and Parathyroid Hormone.

The authors tagged it with the keywords 25-hydroxyvitamin D, Optimal threshold, Vitamin D3 supplementation and Women of childbearing age.

What This Means in Plain Language

The paper is a randomized and parallel-group study of Parathyroid Hormone (PTH 1-84).

The abstract goes on to report its results in about 10 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2025 (European journal of nutrition), a journal based in Germany.

More context: the Parathyroid Hormone (PTH 1-84) compound page, all human trials.