Supplementary zinc and vitamin D in management of symptomatic oral lichen planus: a three-arm randomized clinical trial.

What Was Tested

The paper reports a study of Vitamin D, K2, Magnesium and Zinc, published as a randomized controlled trial.

The current trial was conducted to assess the effect of topical corticosteroid supplemented with zinc or vitamin D compared to topical corticosteroid in management of symptomatic oral lichen planus.

Why It Was Studied

Oral lichen planus (OLP) is a chronic inflammatory disease affecting the oral mucosa, with immune mediated pathogenesis.

Both zinc and vitamin D are essential micronutrients implicated in OLP pathogenesis, with zinc influencing epithelial growth, wound healing, and oxidative stress mitigation, while vitamin D modulates immune cell function, cytokine activity, and keratinocyte behavior.

Who Took Part

By PubMed's age tags, the people studied were adults and middle-aged adults, both men and women.

Forty-two patients diagnosed with symptomatic oral lichen planus (atrophic, erosive, or bullous types) were included in the study, based on clinical examination and histopathological confirmation in accordance with the modified World Health Organization (WHO) criteria (2003).

Participants were divided randomly into three parallel groups.

How the Study Was Run

The design is described as randomized and parallel-group.

The participants were allocated by chance, so the Vitamin D, K2, Magnesium and Zinc group and the comparison group should start out alike.

The Vitamin D, K2, Magnesium and Zinc group and the comparison group ran side by side rather than switching.

Group I received topical corticosteroid; Group II received topical corticosteroid with systemic zinc; Group III received topical corticosteroid with systemic vitamin D.

What Was Measured

Topics PubMed links to this paper include Vitamin D, Zinc, Lichen Planus, Oral, Dietary Supplements, Administration, Topical, Vitamins and Pain Measurement.

Author keywords: Clinical trial, Corticosteroids, Oral lichen planus and Triamcinolone acetonide.

What This Means in Plain Language

The paper is a randomized and parallel-group study of Vitamin D, K2, Magnesium and Zinc.

Its findings take up roughly 5 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2025 (BMC oral health), a journal based in England.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.