Impact of Vitamin D Supplementation on Cognition in Adults With Mild to Moderate Vitamin D Deficiency: Outcomes From the VitaMIND Randomized Controlled Trial.

What Was Tested

This randomized controlled trial looks at Vitamin D, K2, Magnesium and Zinc.

Preserved cognitive health with ageing is a public health imperative.

Who Took Part

The study group was 620 adults.

PubMed indexes the participants as middle-aged adults, older adults and people over 80, both men and women.

Two-arm, parallel, 24-month randomized controlled trial, with vitamin D supplementation compared with a placebo.

This was a remote trial, completed from home involving 620 adults, aged ≥ 50 years, with mild to moderate vitamin D deficiency and early cognitive impairment.

How the Study Was Run

In design terms this was a randomized, placebo-controlled and parallel-group study.

Because people in this Vitamin D, K2, Magnesium and Zinc study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

Some adults received a placebo instead of Vitamin D, K2, Magnesium and Zinc, giving a reference point.

Groups ran in parallel: each of the adults stayed in one arm throughout.

The primary outcome was executive function measured through Trail Making Test Part B and other secondary measures of cognition, function, and well-being.

What Was Measured

The subject headings attached to it are Vitamin D Deficiency, Vitamin D, Dietary Supplements, Cognition, Vitamins and Cognitive Dysfunction.

The authors tagged it with the keywords online, risk and trial.

What This Means in Plain Language

The paper is a randomized, placebo-controlled and parallel-group study of Vitamin D, K2, Magnesium and Zinc in 620 adults.

With several hundred people or more, it is a fairly large study for this kind of research.

Its findings take up roughly 4 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2025 (Journal of the American Medical Directors Association), a journal based in United States.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.