The Effect of Magnesium Sulfate Infusion on Postoperative Opioid Consumption in Abdominal Hysterectomy: A Randomised, Double-Blind Trial.

What Was Tested

The paper reports a study of Vitamin D, K2, Magnesium and Zinc, published as a randomized controlled trial.

To assess the impact of magnesium sulfate infusion on total opioid consumption following abdominal hysterectomy in a clinical setting.

Why It Was Studied

Analgesia, Gynaecologic Anaesthesia, Hysterectomy, Magnesium sulfate, Patient-controlled analgesia, Postoperative pain.

Who Took Part

The study group was 48 participants.

PubMed indexes the participants as adults and middle-aged adults, women only.

Place and Duration of the Study: Department of Gynaecology, Giresun Gynaecology and Children's Diseases Training and Research Hospital, Giresun, Turkiye, from November 2023 to April 2024.

A total of 48 participants were randomly assigned to two groups: Group M (magnesium sulfate infusion) and Group N (placebo).

How the Study Was Run

The design is described as randomized, double-blind and placebo-controlled.

Random assignment meant chance, not the researchers, decided who got Vitamin D, K2, Magnesium and Zinc and who got the comparison, which limits bias.

Blinding on both sides kept the participants and researchers unaware of who received Vitamin D, K2, Magnesium and Zinc.

A placebo (an inactive look-alike) gave the Vitamin D, K2, Magnesium and Zinc group a baseline to be compared against.

Controlled, randomised, prospective, and double-blind trial.

Participants in Group N received an equivalent volume of saline.

The primary outcome was total opioid consumption within the first 24 hours, while secondary outcomes included pain scores, remifentanil use, haemodynamic parameters, and adverse effects.

What Was Measured

Topics PubMed links to this paper include Magnesium Sulfate, Hysterectomy, Postoperative Pain, Analgesics, Opioid and Pain Measurement.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc in 48 participants.

Its findings take up roughly 5 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2025 (Journal of the College of Physicians and Surgeons--Pakistan : JCPSP), a journal based in Pakistan.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.