The interaction of vitamin D supplementation with Omentin-1 gene polymorphism on metabolic biomarkers, omentin-1 levels and anthropometric measures in women with prediabetes: A double-blind randomized controlled trial.

What Was Tested

This randomized controlled trial looks at Vitamin D, K2, Magnesium and Zinc.

Both genetic factors and lifestyle contribute to the development and progression of prediabetes.

Therefore, this trial aimed to investigate the interaction between vitamin D supplementation and the Omentin-1 gene polymorphism on metabolic factors, omentin-1 levels and obesity values in women with prediabetes.

After obtaining informed consent, the blood samples of all participants were analysed to determine the Omentin-1 polymorphism (Val109Asp) genotypes.

Who Took Part

According to the abstract, 204 women were involved.

The age groups tagged for this paper are teenagers, young adults, adults, middle-aged adults and older adults, women only.

This double-blind randomized controlled trial was conducted on 204 women aged 18-65 with prediabetes.

The women were then randomized into intervention (n = 24) and placebo (n = 24) groups (1:1) according to each genotype of the Omentin-1 polymorphism.

How the Study Was Run

The researchers set it up as a randomized, double-blind and placebo-controlled study.

The women were allocated by chance, so the Vitamin D, K2, Magnesium and Zinc group and the comparison group should start out alike.

As a double-blind Vitamin D, K2, Magnesium and Zinc study, the assignments were hidden from both participants and investigators until the end.

The comparison arm used a placebo, so changes seen with Vitamin D, K2, Magnesium and Zinc could be set against what happens without it.

Anthropometric measures, dietary intake data and physical activity level information were collected at the beginning and after the intervention.

Data analyses were performed using IBM SPSS Statistics software.

What Was Measured

Topics PubMed links to this paper include Lectins, GPI-Linked Proteins, Cytokines, Prediabetic State, Biomarkers, Dietary Supplements and Vitamin D.

Author keywords: Omentin‐1, metabolic factors, obesity, polymorphism, prediabetes and women.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc in 204 women.

The abstract goes on to report its results in about 6 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2025 (Diabetes, obesity & metabolism), a journal based in England.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.