Maternal and neonatal vitamin D levels and hyperbilirubinemia: A systematic review and meta-analysis.

What It Covers

This meta-analysis looks at Vitamin D, K2, Magnesium and Zinc.

Vitamin D (Vit D) deficiency during pregnancy may have potential adverse effects on the health of mothers and neonates.

The relationship between Vit D deficiency and neonatal hyperbilirubinemia is unknown.

The aim of this study is to determine the relationship between Vit D levels in mothers and neonates and the occurrence of neonatal hyperbilirubinemia.

Who the Included Studies Covered

PubMed tags the participants as women only.

How the Review Was Done

This systematic review and meta-analysis were guided by Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA).

A literature search was conducted in electronic databases: PubMed, Cochrane, CINAHL, Scopus, Web of Science, Ovid MEDLINE, and MEDLINE Ultimate until the end of 2024 to find studies published in English that investigated Vit D levels in mothers or neonates and their associations with hyperbilirubinemia.

A random effects model was used for (subgroup) meta-analyses, assessing heterogeneity with I-squared, publication bias with funnel plot, Egger and Begg tests, and conducting meta-regression to explore heterogeneity sources.

What Was Measured

Topics PubMed links to this paper include Vitamin D, Vitamin D Deficiency, Hyperbilirubinemia, Neonatal, Hyperbilirubinemia and Pregnancy Complications.

The authors tagged it with the keywords Meta-analysis, Nutrition and Systematic review.

What This Means in Plain Language

This is a meta-analysis of Vitamin D, K2, Magnesium and Zinc.

The abstract goes on to report its results in about 4 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2025 (Clinical nutrition ESPEN), a journal based in England.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.