The value of nanocarbon contrast methylene blue based on dye-based tracer technology in sentinel lymph node biopsy for breast cancer: a systematic review and meta-analysis.

What It Covers

The paper reports a study of Methylene blue (non-peptide stack partner), published as a meta-analysis.

The purpose of this study was to compare the diagnostic value of nanocarbon suspensions and methylene blue injections in sentinel lymph node biopsies of patients with breast cancer based on the dye method.

A systematic search of the PubMed, Embase, Cochrane Library (Central) and Web of Science (SCI Expanded) databases was performed to determine the diagnostic value of carbon nanoparticles in Chinese databases (China National Knowledge Infrastructure (CNKI), VIP, Wanfang, Chinese Biomedical Literature Database (CBM)) for identifying methylene blue in sentinel lymph node biopsies of patients with breast cancer.

The QUADAS2 quality evaluation tool of Review Manager 5.4 was used to evaluate the quality of the included studies.

Who the Included Studies Covered

PubMed tags the participants as women only.

How the Review Was Done

Meta-Disc 1.4 software was used to calculate the extracted valid data and perform a heterogeneity test.

STATA 14.0 software was selected to conduct a sensitivity analysis, and Deek's publication bias test was used for the included studies.

What Was Measured

PubMed files the paper under topics including Breast Neoplasms, Carbon, Coloring Agents, Contrast Media, Methylene Blue, Nanoparticles and Sensitivity and Specificity.

Author keywords: Breast cancer, Diagnostic value and Nanocarbon suspension.

What This Means in Plain Language

This is a meta-analysis of Methylene blue (non-peptide stack partner).

Its findings take up roughly 3 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2025 (PeerJ), a journal based in United States.

More context: the Methylene blue (non-peptide stack partner) compound page, all human trials.