Effect of aerobic or resistance exercise, or both on insulin secretion, ciliary neurotrophic factor, and insulin-like growth factor-1 in dieting older adults with obesity

What Was Tested

The paper reports a study of IGF-1 LR3 in the context of insulin resistance, prediabetes & type 2 diabetes, published as a randomized controlled trial.

Obesity exacerbates age-related changes in metabolic and physical function.

The researchers aimed to assess the effects of various exercise therapies coupled with diet-induced weight loss on insulin secretion and sensitivity and on the levels of circulating Ciliary Neurotrophic Factor (CNTF), its receptor (CNTFRα), and Insulin-like Growth Factor-1 (IGF-1) in older adults with both obesity and frailty.

Who Took Part

The abstract describes 160 adults taking part.

By PubMed's age tags, the people studied were middle-aged adults and older adults, both men and women.

The researchers compared 6-month changes in truncal fat and appendicular lean masses by dual x-ray absorptiometry; CNTF, CNTFRα, and IGF-1 levels by enzyme-linked immunosorbent assay; insulin sensitivity by Homeostatic Model Assessment for Insulin Resistance (HOMA-IR); insulin secretion by Disposition Index (DI) during oral glucose tolerance test; and vastus lateralis muscle gene expression of CNTF and CNTFRα by quantitative polymerase chain reaction.

How the Study Was Run

The researchers set it up as a randomized study.

The adults were allocated by chance, so the IGF-1 LR3 group and the comparison group should start out alike.

Stepwise multiple regression analysis was employed to identify the main predictors of changes in plasma CNTF, DI, and physical function.

This study also utilized additional data collected during the main trial, including Physical Performance Test (PPT) scores, muscle strength, maximal oxygen consumption (VO2peak), body composition by magnetic resonance imaging, and leptin and adiponectin plasma levels.

What Was Measured

The subject headings attached to it are Body Composition, Ciliary Neurotrophic Factor, Diet, Reducing, Exercise, Insulin, Insulin Resistance and Insulin Secretion.

Author keywords: CNTFRα, Elderly, Frailty, Insulin sensitivity, Sarcopenia and Weight loss.

What This Means in Plain Language

The paper is a randomized study of IGF-1 LR3 in 160 adults in people with insulin resistance, prediabetes & type 2 diabetes.

Its findings take up roughly 10 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2025 (Clinical nutrition (Edinburgh, Scotland)), a journal based in England.

More context: the IGF-1 LR3 compound page, Insulin resistance, prediabetes & type 2 diabetes research.