Clinical and radiographic evaluation of topical vitamin D application on immediate dental implants: a randomized clinical trial.

What Was Tested

The paper reports a study of Vitamin D, K2, Magnesium and Zinc, published as a randomized controlled trial.

This study aimed to evaluate the clinical and radiographic effects of topical vitamin D3 (calcitriol) gel on immediate dental implants.

Why It Was Studied

Bioactive agents, such as growth factors, cytokines and vitamins, are explored for their roles in enhancing bone healing and implant osseointegration.

METHODS: Twenty-four immediate implants were placed in healthy patients (aged 21–40 years) requiring replacement of single-rooted teeth in the anterior mandible.

Who Took Part

By PubMed's age tags, the people studied were young adults and adults, both men and women.

How the Study Was Run

The researchers set it up as a randomized study.

Random assignment meant chance, not the researchers, decided who got Vitamin D, K2, Magnesium and Zinc and who got the comparison, which limits bias.

What Was Measured

Clinical evaluations, including peri-implant probing depth, bleeding index, pain score and implant stability, were performed at baseline, 3 and 6 months postoperatively.

Radiographic evaluation, represented by bone density analysis was conducted at the same intervals.

PubMed files the paper under topics including Administration, Topical, Osseointegration, Bone Density, Tooth Extraction, Wound Healing, Immediate Dental Implant Loading and Calcitriol.

Author keywords: Bioactive agents, Calcitriol emulgel, IDRISI kilimanjaro software, Implant stability, Implant surface modifications and Tooth replacement.

What This Means in Plain Language

The paper is a randomized study of Vitamin D, K2, Magnesium and Zinc.

The publication is from 2025 (BMC oral health), a journal based in England.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.