Inappropriate vitamin D supplementation among multimorbid older patients: a multicountry analysis.

What Was Tested

Researchers studied Vitamin D, K2, Magnesium and Zinc in this randomized controlled trial publication.

The prevalence of vitamin D supplementation and the percentage of participants with a lack of appropriate vitamin D supplementation ("potential underuse") or potentially inappropriate vitamin D supplementation ("potential overuse") and risk factors for these are currently unclear.

Who Took Part

By PubMed's age tags, the people studied were older adults and people over 80, both men and women.

Cross-sectional analysis from the OPERAM study, a multicenter cluster randomized controlled trial in four European countries (Belgium, Ireland, The Netherlands, Switzerland) including multimorbid (≥ 3 chronic conditions) older patients, with polypharmacy (≥ 5 chronic medications).

How the Study Was Run

In design terms this was a randomized and multicenter study.

The participants were allocated by chance, so the Vitamin D, K2, Magnesium and Zinc group and the comparison group should start out alike.

Running at several centres spread the Vitamin D, K2, Magnesium and Zinc study over different clinics and patient groups.

What Was Measured

The subject headings attached to it are Cross-Sectional Studies, Vitamin D, Dietary Supplements, Multimorbidity, Risk Factors, Europe and Polypharmacy.

Author keywords: Inappropriate prescribing, Older adults and Overuse.

What This Means in Plain Language

The paper is a randomized and multicenter study of Vitamin D, K2, Magnesium and Zinc.

The abstract goes on to report its results in about 8 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2025 (BMC geriatrics), a journal based in England.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.