Associations between kisspeptin hormone level and its genetic polymorphisms with polycystic ovary syndrome.

What It Covers

Researchers studied Kisspeptin-10 in this meta-analysis publication.

In this study, the researchers conducted meta-analyses to assess the possible association between kisspeptin hormone and its genetic aspect with PCOS.

Additionally, the researchers performed a Mendelian randomization (MR) analysis to clarify the cause-effect relationship of kisspeptin level and the risk of developing PCOS.

The I2 was used to assess heterogeneity.

Why It Was Studied

Polycystic ovary syndrome (PCOS) is among the most common endocrine and metabolic disorders.

Kisspeptin, a neuropeptide, which has been implicated in enhancing hypothalamic-pituitary-ovarian (HPO) axis activity, might play a role in the pathogenesis of PCOS.

Who the Included Studies Covered

PubMed tags the participants as women only.

The reliability, potential biases, and heterogeneity of the results were assessed through inverse variance weighting, MR-Egger regression, Mendelian randomization pleiotropy residual sum and outlier, as well as leave-one-out analysis.

How the Review Was Done

Studies that evaluated the association between the kisspeptin level and/or KiSS-1 metastasis suppressor (KISS1) polymorphisms and PCOS were included for meta-analyses.

Data extraction was performed, and the quality of the studies was assessed using the Newcastle-Ottawa Scale independently by two reviewers.

The causal associations between kisspeptin level and PCOS were assessed using MR methods.

What Was Measured

Exposure SNPs for kisspeptin level were derived from a GWAS dataset from the deCODE database, while the genetic associations for PCOS were obtained from the FinnGen study and the largest GWAS dataset.

Topics PubMed links to this paper include Polycystic Ovary Syndrome, Kisspeptins, Polymorphism, Single Nucleotide, Genome-Wide Association Study, Mendelian Randomization Analysis and Genetic Predisposition to Disease.

The authors tagged it with the keywords KISS1 gene, endocrine and metabolism and meta‐analysis.

What This Means in Plain Language

This is a meta-analysis of Kisspeptin-10.

Its findings take up roughly 12 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2026 (International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics), a journal based in United States.

More context: the Kisspeptin-10 compound page, all human trials.