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The interaction of vitamin D supplementation with Omentin-1 gene polymorphism on metabolic factors and anthropometric indices in women with prediabetes: a study protocol for a double-blind randomized controlled trial.
Plain-language guide to PMID 40770752 (2025): double-blind randomized controlled trial of Vitamin D, K2, Magnesium and Zinc in 144 women.
Key Facts
- PMID
- 40770752
- Journal
- BMC complementary medicine and therapies
- Year
- 2025
- Study type
- Randomized Controlled Trial
- Authors
- Molani-Gol R et al. (4 authors)
- DOI
- 10.1186/s12906-025-05034-2
What This Study Did, in Plain Language
What Was Tested
This randomized controlled trial looks at Vitamin D, K2, Magnesium and Zinc.
Therefore, the primary aim of this trial is to investigate the interaction of vitamin D supplementation with Omentin-1 gene polymorphism on metabolic factors and anthropometric indices in women with prediabetes.
After obtaining informed consent, all participants’ blood samples will be achieved to determine the Omentin-1 polymorphism (Val109Asp) genotypes.
Who Took Part
The abstract describes 144 women taking part.
By PubMed's age tags, the people studied were teenagers, young adults, adults, middle-aged adults and older adults, women only.
How the Study Was Run
The design is described as randomized, double-blind and placebo-controlled.
Because people in this Vitamin D, K2, Magnesium and Zinc study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.
Neither the women nor the staff measuring them knew who was on Vitamin D, K2, Magnesium and Zinc, so expectations could not easily colour the readings.
The comparison arm used a placebo, so changes seen with Vitamin D, K2, Magnesium and Zinc could be set against what happens without it.
What Was Measured
Topics PubMed links to this paper include Lectins, Prediabetic State, Cytokines, Vitamin D, Dietary Supplements, GPI-Linked Proteins and Polymorphism, Genetic.
The authors tagged it with the keywords Omentin-1, Prediabetes, Randomized controlled trial and Women.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc in 144 women.
The publication is from 2025 (BMC complementary medicine and therapies), a journal based in England.
More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.
Our Notes on the Compound
Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.