← Human Trials & Peer-Reviewed Studies
Effect of vitamin D supplementation on inflammatory status and behavioral symptoms in children with autism spectrum disorders: a double-blind randomized clinical trial.
Plain-language guide to PMID 40781660 (2025): double-blind randomized controlled trial of Vitamin D, K2, Magnesium and Zinc in 43 children.
Key Facts
- PMID
- 40781660
- Journal
- BMC pediatrics
- Year
- 2025
- Study type
- Randomized Controlled Trial
- Authors
- Javadfar Z et al. (10 authors)
- DOI
- 10.1186/s12887-025-05985-y
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of Vitamin D, K2, Magnesium and Zinc, published as a randomized controlled trial.
PURPOSE: Inflammation in early childhood has been proposed as a clinically recognized risk factor for developing autism spectrum disorder (ASD).
Since vitamin D has an anti-inflammatory role, this trial was aimed to evaluate the effects of vitamin D supplementation on TNF-α and IL-37 status and behavioral problems in children with ASD.
Why It Was Studied
Moreover, the Real-Life Rating Scale for Autism (RLRS) questionnaire assessed behavioral symptoms.
Who Took Part
The abstract describes 43 children taking part.
PubMed indexes the participants as young children and children, both men and women.
How the Study Was Run
The researchers set it up as a randomized, double-blind and parallel-group study.
The children were allocated by chance, so the Vitamin D, K2, Magnesium and Zinc group and the comparison group should start out alike.
As a double-blind Vitamin D, K2, Magnesium and Zinc study, the assignments were hidden from both participants and investigators until the end.
The Vitamin D, K2, Magnesium and Zinc group and the comparison group ran side by side rather than switching.
Serum levels of 25(OH) D (ng/ml), and inflammatory indices including tumor necrosis factor-alpha (TNF-α) (ng/ml), and interleukin 37 (IL-37) (ng/ml) were measured at the start and end of the study.
What Was Measured
Moreover, the Real-Life Rating Scale for Autism (RLRS) questionnaire assessed behavioral symptoms.
Topics PubMed links to this paper include Autism Spectrum Disorder, Vitamin D, Tumor Necrosis Factor-alpha, Dietary Supplements, Interleukin-1, Inflammation and Vitamins.
The authors tagged it with the keywords Autism spectrum disorders, Behavioral symptoms and Interleukin-37.
What This Means in Plain Language
The paper is a randomized, double-blind and parallel-group study of Vitamin D, K2, Magnesium and Zinc in 43 children.
The publication is from 2025 (BMC pediatrics), a journal based in England.
More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.
Our Notes on the Compound
Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.