Association of semaglutide use with outcomes in chronic plantar heel pain: a prospective observational cohort and a pilot interventional study

What Was Tested

This observational study looks at Semaglutide in the context of chronic pain: fibromyalgia & crps.

Who Took Part

The abstract describes 3000 adults taking part.

By PubMed's age tags, the people studied were adults, middle-aged adults and older adults, both men and women.

In the observational arm, more than 3000 adults with chronic PHP (duration of symptoms >6 months) were recruited with at least 2-year follow-up from two medical centers.

How the Study Was Run

In design terms this was a pilot study.

It is described as a pilot, a small early test of whether a larger Semaglutide study would be practical.

This study included a prospective observational cohort and a pilot interventional component.

The primary endpoint was the change from baseline of Foot Health Status Questionnaire (FHSQ) pain subdomain at the last follow-up.

Secondary endpoints included first-step pain, FHSQ function subdomain, the amount of NSAIDs consumption, number of injection therapies/extracorporeal shockwave therapy (ESWT) sessions/manual stretching, days of orthosis wearing and thickness of plantar fascia.

What Was Measured

Topics PubMed links to this paper include Pilot Projects, Glucagon-Like Peptides, Diabetes Mellitus, Type 2, Chronic Pain, Glucagon-Like Peptide-1 Receptor Agonists, Fasciitis, Plantar and Heel.

Author keywords: GLP1-RA, obesity, plantar fasciitis, plantar heel pain, semaglutide and weight loss.

What This Means in Plain Language

The paper is a pilot study of Semaglutide in 3000 adults in people with chronic pain: fibromyalgia & crps.

With several hundred people or more, it is a fairly large study for this kind of research.

The abstract goes on to report its results in about 9 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2025 (International journal of surgery (London, England)), a journal based in United States.

More context: the Semaglutide compound page, Chronic pain: fibromyalgia & CRPS research.