Effects of physiological doses of atrial natriuretic peptide on lipolysis, ketogenesis, and glucose metabolism in men

What Was Tested

Researchers studied ANP (Atrial Natriuretic Peptide) in this randomized controlled trial publication.

Ten healthy men were randomized to a 1-h infusion of ANP vs. placebo in a crossover design while infused with the stable isotopes: [1,1,2,3,3-D5]-glycerol, potassium-13C16]-palmitate, sodium-D-β-[2,4-13C2]-hydroxybutyrate, and [6,6-D2]-glucose to determine changes in rate of appearance and disappearance of glycerol, palmitate, β-hydroxybutyrate, and glucose.

Why It Was Studied

No effects of ANP infusion were observed in the rate of appearance and rate of disappearance of glycerol, palmitate, β-hydroxybutyrate, or glucose.

Who Took Part

By PubMed's age tags, the people studied were young adults and adults, men only.

How the Study Was Run

The design is described as randomized, placebo-controlled and crossover.

Because people in this ANP (Atrial Natriuretic Peptide) study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

The comparison arm used a placebo, so changes seen with ANP (Atrial Natriuretic Peptide) could be set against what happens without it.

Each person switched between ANP (Atrial Natriuretic Peptide) and the comparison at some point, usually with a gap in between.

What Was Measured

The subject headings attached to it are Lipolysis, Atrial Natriuretic Factor, Glucose, Glycerol, Blood Glucose and Ketone Bodies.

The authors tagged it with the keywords adipose tissue, cGMP, ketogenesis and stable isotope infusion.

What This Means in Plain Language

The paper is a randomized, placebo-controlled and crossover study of ANP (Atrial Natriuretic Peptide).

The publication is from 2025 (American journal of physiology. Endocrinology and metabolism), a journal based in United States.

More context: the ANP (Atrial Natriuretic Peptide) compound page, all human trials.