Comparative evaluation of the effects of diclofenac sodium and vitamin D supplementation on symptoms in individuals with myofascial pain and vitamin D deficiency: a randomized controlled clinical trial.

What Was Tested

Researchers studied Vitamin D, K2, Magnesium and Zinc in this randomized controlled trial publication.

While the etiology of bruxism remains unclear, psychological factors like stress and anxiety, along with central nervous system, are thought that it will provoke.

This randomised trial was approved by the Van Yüzüncü Yıl University Faculty of Medicine Clinical Research Ethics Committee (May 18, 2022, decision no: 05).

Who Took Part

The age groups tagged for this paper are teenagers, young adults and adults, both men and women.

This study included patients aged 18-40, diagnosed with myofascial pain (MP) according to DC/TMD criteria, and individuals with vitamin D deficiency.

Two different treatment methods were applied to the patients.

How the Study Was Run

In design terms this was a randomized study.

Because people in this Vitamin D, K2, Magnesium and Zinc study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

One group received medical treatment with diclofenac sodium and an occlusal splint.

The other group received vitamin D supplementation and an occlusal splint.

The patients' mouth opening and pain scores were evaluated at four stages; before treatment, and 1 week, 4 weeks, 12 weeks after the initiation of treatment.

What Was Measured

Topics PubMed links to this paper include Diclofenac, Vitamin D Deficiency, Vitamin D, Anti-Inflammatory Agents, Non-Steroidal, Dietary Supplements, Temporomandibular Joint Dysfunction Syndrome and Occlusal Splints.

Author keywords: Myofascial pain, TMD, Bruxism, Diclofenac sodium and TMJ.

What This Means in Plain Language

The paper is a randomized study of Vitamin D, K2, Magnesium and Zinc.

Results are reported in around 4 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 2025 (BMC oral health), a journal based in England.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.