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A Systematic Review and Meta-Analysis of the Effects of Vitamin D on Systemic Lupus Erythematosus.
Plain-language guide to PMID 40944182 (2025): meta-analysis of Vitamin D, K2, Magnesium and Zinc, lupus (sle).
Key Facts
- PMID
- 40944182
- Journal
- Nutrients
- Year
- 2025
- Study type
- Meta-Analysis
- Authors
- El Kababi S et al. (10 authors)
- DOI
- 10.3390/nu17172794
What This Paper Covers, in Plain Language
What It Covers
Researchers studied Vitamin D, K2, Magnesium and Zinc in the context of lupus (sle) in this meta-analysis publication.
Background and Objective: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by widespread inflammation and multisystem involvement, leading to substantial morbidity.
Why It Was Studied
Given the immunomodulatory role of vitamin D and its association with disease activity in SLE, supplementation has emerged as a potential therapeutic strategy.
However, findings across individual studies remain inconsistent, underscoring the need for a systematic review and meta-analysis to synthesize the current evidence on vitamin D supplementation for this disease.
Who the Included Studies Covered
By PubMed's age tags, the people studied were adults, both men and women.
Included studies were randomized trials with vitamin D supplementation in patients with SLE and with pre-post intervention measures of disease activity.
Heterogeneity was evaluated using the I2 test, and sensitivity analysis and publication bias assessment were also performed.
What Was Measured
An assessment of the included studies was conducted according to the recommendations of the Cochrane Handbook for Systematic Reviews of Interventions, using the risk of bias assessment tool in Review Manager (Revman) version 5.3.
The subject headings attached to it are Lupus Erythematosus, Systemic, Vitamin D, Dietary Supplements and Randomized Controlled Trials as Topic.
The authors tagged it with the keywords 25-hydroxyvitamin D, autoimmunity, bone mineral density, fatigue, immunomodulation and inflammatory biomarker.
What This Means in Plain Language
This is a meta-analysis of Vitamin D, K2, Magnesium and Zinc in people with lupus (sle).
The publication is from 2025 (Nutrients), a journal based in Switzerland.
More context: the Vitamin D, K2, Magnesium and Zinc compound page, Lupus (SLE) research.
Our Notes on the Compound
Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.