Synergistic effects of exercise, cognitive training and vitamin D on gait performance and falls in mild cognitive impairment-secondary outcomes from the SYNERGIC trial.

What Was Tested

The paper reports a study of Vitamin D, K2, Magnesium and Zinc, published as a randomized controlled trial.

To investigate the synergistic effects of aerobic-resistance exercise combined with cognitive training, with or without vitamin D supplementation, on gait performance and falls risk in older adults with MCI.

Who Took Part

The age groups tagged for this paper are older adults and people over 80, both men and women.

Assessments were conducted at baseline, 6-month endpoint (after intervention) and 12-month endpoint (follow-up).

Eligible participants were between the ages of 65 and 84 years with MCI enrolled from 19 September 2016 to 7 April 2020.

How the Study Was Run

In design terms this was a randomized study.

Because people in this Vitamin D, K2, Magnesium and Zinc study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

Main outcomes of interest for gait performance were gait speed and gait variability changes, whilst for falls were incidental falls and incidental injurious falls.

What Was Measured

PubMed files the paper under topics including Accidental Falls, Vitamin D, Cognitive Dysfunction, Gait, Resistance Training, Exercise Therapy and Dietary Supplements.

The authors tagged it with the keywords Mild Cognitive Impairment, exercises and older people.

What This Means in Plain Language

The paper is a randomized study of Vitamin D, K2, Magnesium and Zinc.

The abstract goes on to report its results in about 6 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2025 (Age and ageing), a journal based in England.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.