Effect of vitamin D and E supplementation on pain relief and premenstrual symptoms in primary dysmenorrhea: a randomized controlled trial.

What Was Tested

Researchers studied Vitamin D, K2, Magnesium and Zinc in this randomized controlled trial publication.

This study aimed to investigate the effects of vitamin D and E supplements combination on pain intensity and premenstrual symptoms in individuals with primary dysmenorrhea.

Why It Was Studied

Primary dysmenorrhea is a common condition characterized by painful menstrual cramps.

In IRCT.ir with number IRCT20220720055506N1 at 2023-02-01.

Who Took Part

The abstract describes 106 participants taking part.

PubMed indexes the participants as young adults and adults, women only.

A double blinded randomized controlled trial was conducted with 106 participants diagnosed with primary dysmenorrhea.

The participants were randomly assigned to either the intervention group (received vitamin D and E supplements) or the control group (received placebo).

How the Study Was Run

The design is described as randomized, double-blind and placebo-controlled.

Random assignment meant chance, not the researchers, decided who got Vitamin D, K2, Magnesium and Zinc and who got the comparison, which limits bias.

As a double-blind Vitamin D, K2, Magnesium and Zinc study, the assignments were hidden from both participants and investigators until the end.

The comparison arm used a placebo, so changes seen with Vitamin D, K2, Magnesium and Zinc could be set against what happens without it.

What Was Measured

Primary dysmenorrhea is a common condition characterized by painful menstrual cramps.

PubMed files the paper under topics including Dysmenorrhea, Vitamin D, Dietary Supplements, Premenstrual Syndrome, Vitamin E, Pain Management and Pain Measurement.

The authors tagged it with the keywords Premenstrual symptoms.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc in 106 participants.

Results are reported in around 5 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 2025 (BMC women's health), a journal based in England.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.