Clinical randomized trial of vitamin D and C supplementation in critically ill patients with respiratory failure.

What Was Tested

Researchers studied Vitamin D, K2, Magnesium and Zinc in this randomized controlled trial publication.

Since vitamin deficiencies are frequent in critically ill patients, and considering that the two primary mechanisms involved in ARF are inflammation and oxidative stress, this study aims to investigate the effects of co-supplementation of vitamins D and C on inflammatory parameters, oxidative stress, and clinical outcomes in critically ill ARF patients.

Why It Was Studied

RESULTS: Thirty-four patients in the intervention group and 33 in the control group completed the trial.

Who Took Part

PubMed indexes the participants as adults, middle-aged adults and older adults, both men and women.

How the Study Was Run

In design terms this was a randomized, double-blind and placebo-controlled study.

Random assignment meant chance, not the researchers, decided who got Vitamin D, K2, Magnesium and Zinc and who got the comparison, which limits bias.

As a double-blind Vitamin D, K2, Magnesium and Zinc study, the assignments were hidden from both participants and investigators until the end.

The comparison arm used a placebo, so changes seen with Vitamin D, K2, Magnesium and Zinc could be set against what happens without it.

What Was Measured

The subject headings attached to it are Critical Illness, Vitamin D, Respiratory Insufficiency, Oxidative Stress, Dietary Supplements, Ascorbic Acid and C-Reactive Protein.

The authors tagged it with the keywords Acute respiratory failure, Inflammation and Vitamin c.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc.

The publication is from 2025 (Nutrition journal), a journal based in England.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.