Comparative Efficacy of Desmopressin, Tranexamic Acid, and Phenylephrine in Reducing Bleeding and Improving Surgical Field Quality during Rhinoplasty: A Triple-Blind Randomized Controlled Trial

What Was Tested

The paper reports a study of Vasopressin and Desmopressin, published as a randomized controlled trial.

IRCT20240712062409N1 LEVEL OF EVIDENCE I: This journal requires that authors assign a level of evidence to each article.

For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .

Who Took Part

According to the abstract, 80 patients were involved.

By PubMed's age tags, the people studied were teenagers, young adults, adults and middle-aged adults, both men and women.

In this triple-blind clinical trial, 80 patients aged 18-50 undergoing rhinoplasty were randomly divided into four groups: tranexamic acid, phenylephrine, desmopressin, and control.

How the Study Was Run

In design terms this was a randomized and double-blind study.

The patients were allocated by chance, so the Vasopressin group and the comparison group should start out alike.

As a double-blind Vasopressin study, the assignments were hidden from both participants and investigators until the end.

Surgical field quality was assessed using the Boezaart scale, and bleeding volume was measured by weighing blood-soaked gauze and suction fluid.

Data were recorded at 15, 30, 45, and 90-minute intervals and analyzed using SPSS 24.

What Was Measured

IRCT20240712062409N1 LEVEL OF EVIDENCE I: This journal requires that authors assign a level of evidence to each article.

PubMed files the paper under topics including Tranexamic Acid, Rhinoplasty, Phenylephrine, Deamino Arginine Vasopressin, Blood Loss, Surgical, Hemostatics and Antifibrinolytic Agents.

The authors tagged it with the keywords Desmopressin, Intraoperative bleeding and Surgical field quality.

What This Means in Plain Language

The paper is a randomized and double-blind study of Vasopressin and Desmopressin in 80 patients.

Results are reported in around 6 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 2026 (Aesthetic plastic surgery), a journal based in United States.

More context: the Vasopressin compound page and the Desmopressin compound page, all human trials.