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Early life vitamin D and neurocognitive abilities at age 6-8 years: a randomized clinical trial and observational analysis.

Plain-language guide to PMID 41071326 (2026): double-blind randomized controlled trial of Vitamin D, K2, Magnesium and Zinc.

Key Facts

PMID
41071326
Journal
European child & adolescent psychiatry
Year
2026
Study type
Randomized Controlled Trial
Authors
Seppälä V et al. (10 authors)
DOI
10.1007/s00787-025-02891-7
Registered trial
NCT04302987, NCT01723852

What This Study Did, in Plain Language

What Was Tested

Researchers studied Vitamin D, K2, Magnesium and Zinc in this randomized controlled trial publication.

Participants were from a Finnish vitamin D double-blind randomized clinical trial and classified themselves white.

Serum 25(OH)D was analyzed from mothers at mean of 11.2 weeks of gestation, and from children at 12.0 and 23.9 months (25(OH)D, mean (SD) = 83.8 (21.7), 102.3 (30.1), 105.5 (28.6) nmol/L, respectively).

Who Took Part

By PubMed's age tags, the people studied were infants, young children and children, both men and women.

Total Intelligence quotient (IQ) score was assessed with Wechsler Intelligence Scale for Children (WISC-IV) and executive functioning with A Developmental Neuropsychological Assessment (NEPSY-II) and parent-rated Behavior Rating Inventory of Executive Function (BRIEF) questionnaire.

How the Study Was Run

In design terms this was a randomized and double-blind study.

Because people in this Vitamin D, K2, Magnesium and Zinc study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

Neither the participants nor the staff measuring them knew who was on Vitamin D, K2, Magnesium and Zinc, so expectations could not easily colour the readings.

What Was Measured

PubMed files the paper under topics including Vitamin D, Child Development, Executive Function, Dietary Supplements, Cholecalciferol, Finland and Neuropsychological Tests.

Author keywords: 25(OH)D, Children and Neurocognitive abilities.

What This Means in Plain Language

The paper is a randomized and double-blind study of Vitamin D, K2, Magnesium and Zinc.

The publication is from 2026 (European child & adolescent psychiatry), a journal based in Germany.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.

Our Notes on the Compound

Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.

Related Pages

Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.