← Human Trials & Peer-Reviewed Studies
Role of desmopressin and enuresis alarm in improving sleep quality in children with primary monosymptomatic nocturnal enuresis: A multicentre prospective, randomised study in mainland China
Plain-language guide to PMID 41101143 (2025): randomized controlled trial study of Vasopressin and Desmopressin in 251 children.
Key Facts
- PMID
- 41101143
- Journal
- Sleep medicine
- Year
- 2025
- Study type
- Randomized Controlled Trial
- Authors
- Lv L et al. (12 authors)
- DOI
- 10.1016/j.sleep.2025.106849
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of Vasopressin and Desmopressin, published as a randomized controlled trial.
Primary monosymptomatic nocturnal enuresis (PMNE) is a prevalent condition in children with a complex pathogenesis.
This study evaluates the effects of desmopressin (DDAVP) and enuresis alarms (EA) on the sleep quality of children with PMNE, using the Children's Sleep Habits Questionnaire (CSHQ).
Who Took Part
The abstract describes 251 children taking part.
PubMed indexes the participants as children, both men and women.
The researchers enrolled 251 children with PMNE from five hospitals in China, randomly assigning them to DDAVP or EA groups.
Participants underwent evaluations at baseline and after 4, 8, and 12 weeks.
How the Study Was Run
In design terms this was a randomized study.
The children were allocated by chance, so the Vasopressin group and the comparison group should start out alike.
What Was Measured
Primary monosymptomatic nocturnal enuresis (PMNE) is a prevalent condition in children with a complex pathogenesis.
This study evaluates the effects of desmopressin (DDAVP) and enuresis alarms (EA) on the sleep quality of children with PMNE, using the Children's Sleep Habits Questionnaire (CSHQ).
The subject headings attached to it are Nocturnal Enuresis, Deamino Arginine Vasopressin, China, Sleep Quality, Clinical Alarms, Surveys and Questionnaires and Antidiuretic Agents.
Author keywords: Children, Desmopressin and Enuresis alarm.
What This Means in Plain Language
The paper is a randomized study of Vasopressin and Desmopressin in 251 children.
Its findings take up roughly 9 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.
The publication is from 2025 (Sleep medicine), a journal based in Netherlands.
More context: the Vasopressin compound page and the Desmopressin compound page, all human trials.
Our Notes on the Compounds
Vasopressin: A 9-amino-acid hormone (antidiuretic hormone) that controls water balance and blood vessel tone; used in septic shock.
Desmopressin: A synthetic vasopressin analog (DDAVP) used for bedwetting, diabetes insipidus and some bleeding disorders.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.