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Effect of vitamin D supplementation during pregnancy and lactation on the development of infants born to Tanzanian women living with HIV: a secondary analysis of a randomised controlled trial.
Plain-language guide to PMID 41120170 (2025): randomized controlled trial of Vitamin D, K2, Magnesium and Zinc.
Key Facts
- PMID
- 41120170
- Journal
- BMJ open
- Year
- 2025
- Study type
- Randomized Controlled Trial
- Authors
- Shobanke T et al. (9 authors)
- DOI
- 10.1136/bmjopen-2024-098723
- Registered trial
- NCT02305927
What This Study Did, in Plain Language
What Was Tested
Researchers studied Vitamin D, K2, Magnesium and Zinc in this randomized controlled trial publication.
This study evaluated the effect of maternal vitamin D supplementation on infant development outcomes.
Why It Was Studied
Infants born to pregnant women living with HIV (WLHIV) are at greater risk for morbidity and mortality and may also have poorer developmental outcomes as compared with infants who are not exposed to HIV.
Nutrition interventions in pregnancy may affect developmental outcomes.
Who Took Part
The age groups tagged for this paper are infants and adults, both men and women.
The researchers conducted a secondary analysis of a randomised, triple-blind, placebo-controlled trial of maternal vitamin D supplementation from June 2015 to October 2019.
How the Study Was Run
The design is described as randomized and placebo-controlled.
The participants were allocated by chance, so the Vitamin D, K2, Magnesium and Zinc group and the comparison group should start out alike.
A placebo (an inactive look-alike) gave the Vitamin D, K2, Magnesium and Zinc group a baseline to be compared against.
Antenatal care clinics in Dar es Salaam, Tanzania.
Pregnant WLHIV and their offspring.
What Was Measured
Infants born to pregnant women living with HIV (WLHIV) are at greater risk for morbidity and mortality and may also have poorer developmental outcomes as compared with infants who are not exposed to HIV.
Nutrition interventions in pregnancy may affect developmental outcomes.
The subject headings attached to it are Child Development, Dietary Supplements, HIV Infections, Lactation, Pregnancy Complications, Infectious, Prenatal Care and Tanzania.
Author keywords: HIV & AIDS and Nutrition.
What This Means in Plain Language
The paper is a randomized and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc.
Its findings take up roughly 5 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.
The publication is from 2025 (BMJ open), a journal based in England.
More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.
Our Notes on the Compound
Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.