Effects of vitamin D supplementation on metabolic factors, serum omentin-1, and anthropometric indices in middle-aged women with prediabetes: a double-blind randomized controlled trial.

Plain-language guide to PMID 41145460 (2025): double-blind randomized controlled trial of Vitamin D, K2, Magnesium and Zinc.

Key Facts

PMID: 41145460
Journal: Nutrition & diabetes
Year: 2025
Study type: Randomized Controlled Trial
Authors: Molani-Gol R et al. (4 authors)
DOI: 10.1038/s41387-025-00402-w

What This Study Did, in Plain Language

What Was Tested

Researchers studied Vitamin D, K2, Magnesium and Zinc in this randomized controlled trial publication.

The present study aimed to investigate the impact of vitamin D supplementation on metabolic factors, serum omentin-1 levels, and anthropometric indices in women with prediabetes.

Why It Was Studied

Prediabetes is a public health concern, and its prevalence is growing around the world.

Who Took Part

The age groups tagged for this paper are teenagers, young adults, adults, middle-aged adults and older adults, women only.

This randomized controlled trial (RCT) study was carried out on women with prediabetes aged 18-65 years.

Fasting blood samples, anthropometric measurements, and information about the dietary intake and physical activity of the participants were collected at the beginning and after the intervention.

How the Study Was Run

The design is described as randomized, double-blind and placebo-controlled.

The participants were allocated by chance, so the Vitamin D, K2, Magnesium and Zinc group and the comparison group should start out alike.

Neither the participants nor the staff measuring them knew who was on Vitamin D, K2, Magnesium and Zinc, so expectations could not easily colour the readings.

Some participants received a placebo instead of Vitamin D, K2, Magnesium and Zinc, giving a reference point.

Data analyses were done using IBM SPSS Statistics software.

What Was Measured

The subject headings attached to it are Prediabetic State, Lectins, Vitamin D, Dietary Supplements, Cytokines, GPI-Linked Proteins and Insulin.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc.

Results are reported in around 5 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 2025 (Nutrition & diabetes), a journal based in England.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.

Our Notes on the Compound

Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.

Vitamin D, K2, Magnesium and Zinc in the library

Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.