Vitamin D3 Supplementation Modulates Inflammatory Protein CHI3L1/YKL-40 and Oxidative Stress Status in Multiple Sclerosis.

What Was Tested

Researchers studied Vitamin D, K2, Magnesium and Zinc in the context of multiple sclerosis in this clinical trial publication.

Multiple sclerosis (MS) is characterized by chronic neuroinflammation and oxidative stress.

Vitamin D is believed to exert immunomodulatory and antioxidant effects, yet its impact on specific inflammatory proteins such as CHI3L1 (YKL-40) in MS remains unclear.

This study evaluated whether 8-week vitamin D3 supplementation affects serum CHI3L1 levels, oxidative stress markers, and antioxidant enzyme activities in patients with MS.

Who Took Part

The study group was 35 patients.

PubMed indexes the participants as adults and middle-aged adults, both men and women.

How the Study Was Run

Serum 25(OH)D and CHI3L1 levels were determined using commercial enzyme-linked immunosorbent assay (ELISA) kits. oxidative stress markers were measured pre- and post-intervention using commercial colorimetric kits.

Statistical analysis was performed using paired t-tests or Wilcoxon signed-rank tests.

What Was Measured

Topics PubMed links to this paper include Oxidative Stress, Cholecalciferol, Multiple Sclerosis, Chitinase-3-Like Protein 1, Dietary Supplements, Vitamin D and Vitamins.

The authors tagged it with the keywords CHI3L1 (YKL‐40), antioxidant enzymes and vitamin D3.

What This Means in Plain Language

This is a clinical trial of Vitamin D, K2, Magnesium and Zinc in 35 patients in people with multiple sclerosis.

With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.

Its findings take up roughly 6 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2025 (Neuropsychopharmacology reports), a journal based in United States.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, Multiple sclerosis research.