Effects of Resistance Training Combined with Vitamin D Supplementation on Health-Related Variables in the Elderly: Muscle Strength, Body Composition, and Inflammatory Status.

Plain-language guide to PMID 41302641 (2025): randomized controlled trial of Vitamin D, K2, Magnesium and Zinc in 26 participants.

Key Facts

PMID: 41302641
Journal: International journal of environmental research and public health
Year: 2025
Study type: Randomized Controlled Trial
Authors: Rosa LCRD et al. (8 authors)
DOI: 10.3390/ijerph22111695

What This Study Did, in Plain Language

What Was Tested

Researchers studied Vitamin D, K2, Magnesium and Zinc in this randomized controlled trial publication.

This study aimed to investigate the effects of 12 weeks of RT combined with vitamin D supplementation on body composition, muscle strength, and inflammatory status in older adults.

Why It Was Studied

This condition can be mitigated by resistance training (RT) and vitamin D supplementation, promoting the health of this population.

Who Took Part

The study group was 26 participants.

By PubMed's age tags, the people studied were older adults, both men and women.

Before and after the intervention, participants were assessed using DEXA, strength tests (sit-to-stand test and handgrip strength), and serum biomarkers (IL-6, TNF-α, 25(OH)D).

How the Study Was Run

The researchers set it up as a randomized and placebo-controlled study.

Random assignment meant chance, not the researchers, decided who got Vitamin D, K2, Magnesium and Zinc and who got the comparison, which limits bias.

The comparison arm used a placebo, so changes seen with Vitamin D, K2, Magnesium and Zinc could be set against what happens without it.

What Was Measured

PubMed files the paper under topics including Resistance Training, Muscle Strength, Body Composition, Vitamin D, Dietary Supplements, Inflammation and Vitamins.

The authors tagged it with the keywords IL-6, Inflammatory markers, TNF-α, aging, health promotion and older adults.

What This Means in Plain Language

The paper is a randomized and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc in 26 participants.

With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.

The publication is from 2025 (International journal of environmental research and public health), a journal based in Switzerland.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.

Our Notes on the Compound

Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.

Vitamin D, K2, Magnesium and Zinc in the library

Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.