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Impact of Vitamin D Supplementation on IVF Outcomes in Vitamin D-Deficient Poor Responders: a Randomized Controlled Trial.
Plain-language guide to PMID 41413681 (2026): double-blind randomized controlled trial of Vitamin D, K2, Magnesium and Zinc.
Key Facts
- PMID
- 41413681
- Journal
- Reproductive sciences (Thousand Oaks, Calif.)
- Year
- 2026
- Study type
- Randomized Controlled Trial
- Authors
- Mirsharifi MS et al. (4 authors)
- DOI
- 10.1007/s43032-025-02022-2
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of Vitamin D, K2, Magnesium and Zinc, published as a randomized controlled trial.
OBJECTIVE: This study aimed to evaluate the effect of vitamin D supplementation on in vitro fertilization (IVF) outcomes in poor responder women with vitamin D deficiency, focusing on fertilization rates, oocyte quality, and pregnancy rates.
Why It Was Studied
METHODS: A randomized, double-blinded, placebo-controlled trial was conducted at a tertiary referral center (February 2022–2024).
Both groups underwent a GnRH-antagonist protocol.
Who Took Part
By PubMed's age tags, the people studied were adults, women only.
How the Study Was Run
The design is described as randomized, double-blind and placebo-controlled.
The participants were allocated by chance, so the Vitamin D, K2, Magnesium and Zinc group and the comparison group should start out alike.
Neither the participants nor the staff measuring them knew who was on Vitamin D, K2, Magnesium and Zinc, so expectations could not easily colour the readings.
The comparison arm used a placebo, so changes seen with Vitamin D, K2, Magnesium and Zinc could be set against what happens without it.
What Was Measured
Primary outcomes included fertilization rate (2PN oocytes) and oocyte maturity (germinal vesicle (GV), metaphase I (MI), and metaphase II (MII) stages).
PubMed files the paper under topics including Fertilization in Vitro, Vitamin D, Vitamin D Deficiency, Pregnancy Rate, Dietary Supplements, Ovulation Induction and Infertility, Female.
The authors tagged it with the keywords IVF outcomes, Ovarian reserve and Poor responders.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc.
The publication is from 2026 (Reproductive sciences (Thousand Oaks, Calif.)), a journal based in United States.
More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.
Our Notes on the Compound
Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.