Can vitamin D supplementation be dangerous? 25-Hydroxyvitamin D and 1,25-hydroxyvitamin D concentration in healthy population and primary hyperparathyroidism: a single-center experience and literature review.

What It Covers

The paper reports a study of Vitamin D, K2, Magnesium and Zinc and Parathyroid Hormone (PTH 1-84) in the context of hyperparathyroidism, published as a review.

Primary hyperparathyroidism (PHPT) is an excessive secretion of PTH caused by a defect in parathyroid cells, insensitive to the suppressive effects of hypercalcemia.

The effect of 25-hydroxyvitamin D3 (25-OH-D) and skeletal and extra-skeletal conditions is well known, but the impact of 25-OH-D and 1,25-OH-D in the pathogenesis of primary hyperparathyroidism (PHPT) is still poorly researched.

Who the Included Studies Covered

PubMed indexes the participants as adults, middle-aged adults and older adults, both men and women.

How the Review Was Done

Serum PTH, calcium and phosphates concentration were assessed as well as the concentration of 25-OH-D and 1,25-OH-D.

What Was Measured

Primary hyperparathyroidism (PHPT) is an excessive secretion of PTH caused by a defect in parathyroid cells, insensitive to the suppressive effects of hypercalcemia.

The effect of 25-hydroxyvitamin D3 (25-OH-D) and skeletal and extra-skeletal conditions is well known, but the impact of 25-OH-D and 1,25-OH-D in the pathogenesis of primary hyperparathyroidism (PHPT) is still poorly researched.

Topics PubMed links to this paper include Hyperparathyroidism, Primary, Vitamin D, Dietary Supplements, Calcium, Parathyroid Hormone, Vitamin D Deficiency and Calcitriol.

Author keywords: 1,25 hydroxyvitamin D, 25 hydroxy vitamin D and primary hyper parathyroidism.

What This Means in Plain Language

This is a review of Vitamin D, K2, Magnesium and Zinc and Parathyroid Hormone (PTH 1-84) in people with hyperparathyroidism.

The publication is from 2025 (Frontiers in endocrinology), a journal based in Switzerland.

More context: the Vitamin D, K2, Magnesium and Zinc compound page and the Parathyroid Hormone (PTH 1-84) compound page, Hyperparathyroidism research.