The effects of vitamin D levels on risk and prognosis of ovarian cancer: a systematic review.

What It Covers

This systematic review looks at Vitamin D, K2, Magnesium and Zinc.

Ovarian cancer is the eighth most common cancer in women with the highest mortality rate of all gynecological cancers.

Serum vitamin D level has been explored as a possible modifiable risk factor for development and progression of this disease.

The proposed study aims to answer the questions: do women with low levels of vitamin D have a higher risk for developing ovarian cancer and, do low vitamin D levels at the time of ovarian cancer diagnosis predict a poorer prognosis?

Who the Included Studies Covered

PubMed tags the participants as women only.

How the Review Was Done

A systematic search was performed in PubMed, CINAHL, Cochrane, and Scopus.

Cohort, case-control, in vivo, in vitro, and ex vivo studies assessing the effect of vitamin D levels on the risk of developing ovarian cancer, prognosis at time of diagnosis of ovarian cancer, or both, published in English since July of 2008 were included.

Eighteen studies were included in this review.

What Was Measured

The subject headings attached to it are Case-Control Studies, Ovarian Neoplasms, Prognosis, Risk Factors, Vitamin D and Vitamin D Deficiency.

Author keywords: Calcitriol, Ovarian cancer and Systematic review.

What This Means in Plain Language

This is a systematic review of Vitamin D, K2, Magnesium and Zinc.

The abstract goes on to report its results in about 6 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2025 (Cancer causes & control : CCC), a journal based in Netherlands.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.