Effect of vitamin D supplementation on skeletal muscle function and quality of life in patients with chronic intestinal failure: a randomized controlled trial : Clean version.

What Was Tested

Researchers studied Vitamin D, K2, Magnesium and Zinc in this randomized controlled trial publication.

METHODS: This was a single-center, prospective, randomized, double-blind, placebo-controlled trial conducted at a tertiary hospital in China.

Participants included individuals aged 18–70 years with chronic intestinal failure and vitamin D deficiency (serum 25(OH)D < 30 ng/ml).

Who Took Part

By PubMed's age tags, the people studied were teenagers, young adults, adults, middle-aged adults and older adults, both men and women.

RESULTS: Eighty-four patients were randomized to the control group (n = 42; mean age, 52.8 ± 15.6 years) or the vitamin D group (n = 42; mean age, 52.9 ± 16.2 years).

How the Study Was Run

In design terms this was a randomized, double-blind and placebo-controlled study.

The participants were allocated by chance, so the Vitamin D, K2, Magnesium and Zinc group and the comparison group should start out alike.

As a double-blind Vitamin D, K2, Magnesium and Zinc study, the assignments were hidden from both participants and investigators until the end.

The comparison arm used a placebo, so changes seen with Vitamin D, K2, Magnesium and Zinc could be set against what happens without it.

What Was Measured

Participants included individuals aged 18–70 years with chronic intestinal failure and vitamin D deficiency (serum 25(OH)D < 30 ng/ml).

The primary outcomes were appendicular skeletal muscle mass index (assessed by bioelectrical impedance), handgrip strength, 6-meter walking speed, and quality of life (SF-36 scales) from the date of randomization to the end of the 12-week follow-up period.

PubMed files the paper under topics including Quality of Life, Muscle, Skeletal, Vitamin D, Dietary Supplements, Intestinal Failure, Chronic Disease and Vitamin D Deficiency.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc.

The publication is from 2025 (Journal of translational medicine), a journal based in England.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.